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![]() Karima Rjiba-Touati, Imen Ayed-Boussema, Chayma Bouaziz, Anis Belarbia, Awatef Azzabi, Abdelatif Achour, Wafa Hassen, Hassen Bacha.Cisplatin and ultra-violet-C synergistically down-regulate receptor tyrosine kinases in human colorectal cancer cells. Junji Kawaguchi, Seiji Adachi, Ichiro Yasuda, Takahiro Yamauchi, Masanori Nakashima, Tomohiko Ohno, Masahito Shimizu, Takashi Yoshioka, Masahiko Itani, Osamu Kozawa, Hisataka Moriwaki.MutS homologue hMSH5: role in cisplatin-induced DNA damage response. Joshua D Tompkins, Xiling Wu, Chengtao Her.Angewandte Chemie International Edition 2012, 51 Platinum/Thiazole Complex Interferes with Sp1 Zinc-Finger Protein. Siming Chen, Dechen Xu, Huan Jiang, Zhaoyong Xi, Pingping Zhu, Yangzhong Liu.Cisplatin Induces a Mitochondrial-ROS Response That Contributes to Cytotoxicity Depending on Mitochondrial Redox Status and Bioenergetic Functions. Rossella Marullo, Erica Werner, Natalya Degtyareva, Bryn Moore, Giuseppe Altavilla, Suresh S.Journal of Cellular Biochemistry 2014, 115 High Expression of SGTA in Esophageal Squamous Cell Carcinoma Correlates With Proliferation and Poor Prognosis. Xiaojing Yang, Lei Cheng, Mei Li, Hui Shi, Hanru Ren, Zongmei Ding, Fang Liu, Yuchan Wang, Chun Cheng.Pharmacological activation of NQO1 increases NAD+ levels and attenuates cisplatin-mediated acute kidney injury in mice. Gi-Su Oh, Hyung-Jin Kim, Jae-Hyuck Choi, AiHua Shen, Seong-Kyu Choe, Anzani Karna, Seung Hoon Lee, Hyang-Jeong Jo, Sei-Hoon Yang, Tae Hwan Kwak, Chul-Ho Lee, Raekil Park, Hong-Seob So.Upregulation of SYF2 in esophageal squamous cell carcinoma promotes tumor cell proliferation and predicts poor prognosis. Junya Zhu, Lili Ji, Jianguo Zhang, Lei Yang, Chengqi Guan, Yayun Wang, Jia Zhu, Li Liang, Runzhou Ni.) with uracil and small peptide moieties: an experimental and computational study. Physicochemical properties of the ternary complexes of Pt( Shilpi Mandal, Gunajyoti Das, Hassan Askari.Modulatory role of resveratrol on cytotoxic activity of cisplatin, sensitization and modification of cisplatin resistance in colorectal cancer cells. Dimethylsulfoxide excerbates cisplatin-induced cytotoxicity in Ehrlich ascites carcinoma cells. Hydroxamic acids: synthesis and adjuvant activity in combinatorial anticancer therapy. Coordination Chemistry Reviews 2017, 351, 2-31. Cytotoxic platinum coordination compounds. Viktor Brabec, Ondrej Hrabina, Jana Kasparkova.Cisplatin: The first metal based anticancer drug. International Journal of Molecular Sciences 2020, 21 Different Effects of Cisplatin and Transplatin on the Higher-Order Structure of DNA and Gene Expression. Toshifumi Kishimoto, Yuko Yoshikawa, Kenichi Yoshikawa, Seiji Komeda.Links between cancer metabolism and cisplatin resistance. Veronica Cocetta, Eugenio Ragazzi, Monica Montopoli.Experimental and Molecular Pathology 2020, 112, 104324. Evaluation of the protective effects of amifostine and melatonin against cisplatin induced testis injury via oxidative stress and apoptosis in rats. Huseyin Eren, Tolga Mercantepe, Levent Tumkaya, Filiz Mercantepe, Eyup Dil, Mustafa Ozan Horsanali, Adnan Yilmaz. ![]() How can the cisplatin analogs with different amine act on DNA during cancer treatment theoretically?.
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![]() ![]() The "Paris Morton Music 2" section features Drake "proclaiming his once-in-a-generation greatness amid upscale-retail piano tinkling." The closing line of the song and album, is also the album's title "the tone is neither rueful nor celebratory as much as simply matter-of-fact." Wu-Tang Clan's " C.R.E.A.M." is sampled on "Pound Cake", where the chorus is chopped throughout the song. Jay-Z's verse on "Pound Cake" has him referencing pop-culture and rapping in foreign languages. ![]() The song features them both rapping on the "Pound Cake" side of the song, with "Paris Morton Music 2" being a solo Drake track. Drake called the song a sequel, to his previous collaboration with Jay-Z "Light Up", which was featured on his debut album Thank Me Later. It then leaked along with the rest of the album on September 15, 2013. Leading up to the album's release, "Pound Cake" / "Paris Morton Music 2" was one of the most anticipated songs from Nothing Was the Same. "Paris Morton" is the name of a model who Drake wrote the first " Paris Morton Music" about, which was an extended verse from his Rick Ross collaboration " Aston Martin Music". However, Jay-Z gave the song back to Drake, so he could use it on Nothing Was the Same. Following that, he sent "Pound Cake" to Jay-Z, who wanted to use the song for his twelfth studio album Magna Carta Holy Grail. OVO Sound producer Boi-1da then created an instrumental that Drake decided to use for the song. ![]() Jay-Z sent Drake his two verses a cappella for "Pound Cake", who Noah "40" Shebib" created a beat for, but Drake decided was not right for the song. In September 2013, Drake appeared on the cover of Billboard, where in the interview he stated he had two Jay-Z verses on the outro track of Nothing Was the Same. "Pound Cake" was later serviced to radio in the United Kingdom on September 26, 2013, as the album's fourth single, and was subsequently added to the BBC Radio 1Xtra playlist. The track peaked at number 65 on the US Billboard Hot 100 chart. "Paris Morton Music 2" was produced by Detail. "Pound Cake" features a significant sample of "Don't Say A Word" by Ellie Goulding, "Jimmy Smith Rap" by Jimmy Smith, as well as " C.R.E.A.M." by the Wu-Tang Clan, and was produced by frequent collaborator Boi-1da and Jordan Evans. The track serves as the outro to the standard edition of Nothing Was the Same. The track consists of two songs, "Pound Cake" featuring a guest appearance by Jay-Z, and "Paris Morton Music 2", a sequel to "Paris Morton Music". " Pound Cake" / "Paris Morton Music 2" is a song by Canadian rapper Drake from his third studio album Nothing Was the Same released in 2013. ![]() ![]() ![]() Kevin Kline is also on board as a shrink-turned-veterinarian (only in a movie like this) who offers Lilly a reluctant hand with both her shaky emotional state and her fine feathered foe. Like much else here, what happens is - in theory - affecting, but doesn’t play out strongly or credibly enough to match its desired effect. The bird plays a more integral part toward the end of the film, but it’s a turn that feels so predictably contrived and symbolic that it takes the story down with it. But unlike this year’s superior (and true-life) trauma drama “Penguin Bloom,” in which the arrival of an injured magpie helps an accident victim heal her soul, the starling often feels beside the point and only tenuously connected to the action. Vincent”) than because of any true depth of character or authentic emotional dissection.Īnd then there’s that pesky title character: an aggressive and territorial starling that invades Lilly’s space, pecks away at her garden and knocks her to the ground so often she starts wearing a helmet and even tries to poison the bird. But that’s due more to the casting of McCarthy and O’Dowd, a pair of uncommonly engaging actors (they also appeared together in “Bridesmaids” and Melfi’s fine “St. We want to sympathize with Lilly and Jack - she’s a supermarket worker holding down the fort at home (a lovely country house she inherited), he’s a grade-school teacher being treated in a mental health facility for unmanageable depression - and root for them to find their way back to the world and each other. There are strong, relatable themes here, particularly involving the different ways parents may grieve the loss of a child and the attendant guilt, resentment and confusion that can divide a couple at a time when they need to unite the most.īut “The Starling,” directed by Theodore Melfi ( “Hidden Figures”), is no “Ordinary People” (few movies are) and screenwriter Matt Harris’ overreliance on whimsy and a seemingly desperate need to tug at our hearts - instead of our minds - undercuts the film’s more valid situations and sentiments. ![]() (More specifics about the girl’s demise - and less about her bedroom décor - wouldn’t have hurt.) That’s just one of several problems with this forced dramedy about Lilly (Melissa McCarthy) and Jack (Chris O’Dowd), a married couple muddling through life a year after losing their baby daughter from, apparently, sudden infant death syndrome. It turns out, she’s speaking for all of us. The metaphors swoop in so shamelessly in “The Starling” that, at one point, even the film’s protagonist calls someone out for his blatant messaging (“Real subtle stuff, Larry!”). Because moviegoing carries risks during this time, we remind readers to follow health and safety guidelines as outlined by the Centers for Disease Control and Prevention and local health officials. ![]() The Times is committed to reviewing theatrical film releases during the COVID-19 pandemic. ![]() ![]() ![]() Not every single animal in the game can be tamed, but at this point you will be able to tame any of the ones that are possible. NEW Far Cry Primal Walkthrough Gameplay Part 1 includes a Review and Mission 1 of the Main Story for PS4, Xbox One and PC. All three of them are awesome all-rounder animal companions as they function as enemy detectors to their owners. ![]() After taming eight total, you can unlock the Tame Cunning Beasts skill for three skill points, which allows you to tame cave bears and badgers.Īfter unlocking these four, you will have all of the taming Beast Master skills at your disposal. Far Cry Primal gives three varieties of wolves the Wolf, the White Wolf (stronger and faster attacks), and the legendary Rare Striped Wolf (faster, stronger, and fire-resistant). This one will also require you to do some more work on the side, as you need to have tamed a total of eight beasts, which means you need to tame an additional three beyond the Apex Predators skills. With the first three Beast Master taming skills unlocked, that means you have one more level to obtain. Upon taming five beasts, you can then unlock this skill by expending two skill points, which will allow you to tame sabretooth tigers and brown bears. Far Cry animals Far Cry 2 animals Far Cry 3 animals Far Cry 3: Blood Dragon animals Far Cry 4 animals Far Cry Primal animals Far Cry 5 animals Far Cry New. The next level will require you to do some more work on the side to unlock, as you will need to have tamed five different beasts to even unlock the Tame Apex Predators skill. ![]() This will cost you one skill point to unlock, which will then be permanent at that point. Have a Far Cry 6 question or want more information? Head to our frequently asked questions page for some quick info.īe sure to tag your spoilers wrapped around arrows and exclamation points.After taming the wolf as part of the game’s main story, you will have access to the next of the Beast Master skills called Tame Wildcats, which will allow you to tame leopards, jaguars, rare black jaguars, cave lions, and rare black lions. After you have familiarized yourself with our rules feel free to post videos, pictures or discuss anything Far Cry related. Before you start browsing be sure to read and follow the rules of this subreddit. ![]() ![]() ![]() He is attacked by two snake demons but Xiaoqian protects him from them and is injured herself in the explosion. The next day, Ning goes back to the temple with an underwater bomb, intending to blow up the well and release water for the village. Ning and Xiaoqian flee and hide in a tree, where he offers her candy. Yan Chixia arrives and starts slaying the other demons. Xiaoqian shows up and attempts to seduce Ning, but he rejects her. The women are actually demons in disguise and they suck the life out of the men to feed Laolao with "life energy". While Ning investigates the well, the other men notice some beautiful women in the temple and follow them further in. A strange wind blows and they all run up the hill to a temple called Lanruo Temple, where they find a well. They stop for a break in a glade, and Ning goes inside a hollow tree and offers candy to a tiny, pale fox he sees there. Glad to be free, Ning goes up the hill, accompanied by a guide and five convicts, the only men the villagers are willing to send away with him. He is surrounded by the villagers, who initially accused him of stealing water because they are experiencing a drought, but later mistake him for an official sent by the government to help them find a new water source. Many years later, a tax collector named Ning Caichen passes by a village near Black Hill and stops to drink from a well. The last one, Xia Xuefenglei, embeds his arm into Laolao and tells Yan to chop it off, thereby banishing Laolao from the mortal world. ![]() Yan arrives late for a battle against the Tree Demon, Laolao, and sees that several of his fellow demon hunters have already fallen. Yan stabs her with his magic dagger, which does not kill Xiaoqian, but causes her to lose her memory of their relationship. After some time, she begs him to kill her because humans and demons are not supposed to be together. Xiaoqian also falls in love with Yan, and while he feeds her candy, she says she will fall in love with anyone who fed her candy. After capturing an attractive female demon, Nie Xiaoqian, Yan falls in love with her and realises that his master sent him there to make him learn how to control his emotions. ![]() Yan Chixia's master sent him to Black Hill to train in the arts of demon hunting. 3 Connection to A Chinese Ghost Story (1987).Could Ishak be next on the list, or is he the man responsible? Tracking down his more ‘unsavoury’ allies, Serena is shocked to encounter a familiar face: that of her grieving ex-partner, former Malaysian ICD officer Megat Jamil (Bront Palarae). As Serena and Heri work together to catch the killer, their inquiries lead them to industrialist/kingpin Datuk Ishak Hassan (Wan Hanafi Su), whose prominent family and known associates all have some connection to the victims. Seeking answers, Heri finds a way to insert himself into the Malaysian investigation. Meanwhile, in Jakarta, for ICD Lieutenant Heriyanto Salim (Ario Bayu), the case turns personal when his brother is found murdered in similar circumstances. Called in to investigate, Singaporean International Crimes Division (ICD) officer Serena Teo (Rebecca Lim) takes charge of a case across the border where a family has been slaughtered aboard a luxury yacht in Johor. A series of brutal murders, each sharing a signature MO, takes place across Malaysia and Indonesia. ![]() ![]() ![]() You can even play cops and robbers! It’s $2.99. Cars drive, boats sail by, and airplanes zoom across the sky. People move around, including in and out of buildings. Build with just a series of taps on the screen. The game is deceptively simple, but chances are very good that your youngster will quickly become addicted. The app is simple to use, and there are no distracting animations or in-game currency systems to worry about. Kids control basic aspects like weather, vehicles, and lighting. Blox 3D City Creator has the flexibility to create bustling metropolises or sleepy little villages. Your child will enjoy pure, creative fun in its simplest form with this app. Everything was created with young children in mind, and their privacy policy is readily available. This game was designed by a top company with numerous children’s apps, so parents can rest assured there are no in-app purchases or outside advertisements. Players must “discover” the different types of buildings they can create, but there’s an interactive glossary that saves directions to build each type so they can recreate them whenever they want. Kids will be able to experiment with many kinds of building materials and even save multiple cities so they can experiment and return to their creations. It’s simple to use, yet has loads of features. Here’s a fabulous app for the youngest city-builders. ![]() One of the neatest features is the recording mode, that allows players to make videos of their stories as they play in Toca City. There are no in-app purchases or outside advertisements, so you can count on its safety. Kids can play for hours as they shop, try out foods and change their characters’ customization. There are 6 locations to visit and 34 characters to meet and interact with. Toca Life: City is one of a series of apps that really lets your kids get into city building! It starts with loads of options to customize your character, then builds outward as players explore the world.īegin by choosing an outfit (one of hundreds of options) and by picking a hairstyle (47 to choose from). ![]() For Beginning Builders (Ages 6 & Up) Toca Life: City Check out these great city-building apps that are perfect for kids. And imagine the feelings of accomplishment that go with having an entire city at your beck and call! Plus, many of these games are incredible learning experiences. There’s nothing like a city building game to help kids exercise and develop those vital skills. It also takes planning, persistence, and a host of other important skills to be successful. There’s something about the power and the glory of building that keeps kids engaged. Here Are Our Top Picks.įrom the youngest to the oldest, kids go for city-building apps in all their forms. We Reviewed Dozens Of The Best City Building Apps for Kids So You Don’t Have To. ![]() |
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